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IRR, GST-tag Recombinant
IRR, GST-tag Recombinant
Artikelnummer
BPS40242
Verpackungseinheit
10 µg
Hersteller
BPS Bioscience
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Encompassing Amino Acids: 945-end
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Background: IRR or insulin receptor-related receptor is a tyrosine protein kinase that is required for the appearance of male gonads and thus for male sexual differentiation (1). The expression of IRR mRNA is restricted to a few tissue types and has been detected in neuronal tissues as well as in neuroblastomas. As a result of its occurrence in neuroblastomas, it has speculated that IRR may be involved in tumor genesis. RT-PCR and solution hybridization/RNAse protection assay have shown strong coupling of IRR mRNA in 18 tumor cell lines (2).
Description: Recombinant human Insulin receptor-related receptor (IRR), a.a. 945-end, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
Format: Aqueous buffer solution
Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Genbank: NM_014215
Host Cell Line: Sf9 cells
Purity: ≥75%
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal GST-tag
Uniprot: P14616
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Zhang, B. and Roth, R.A. The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities. J. Biol. Chem. 1992; 267 (26): 18320-8.
2. Elmlinger, M.W. et al: Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin. Regul. Pept., 1999; 84 (1-3): 37-42.
Encompassing Amino Acids: 945-end
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Background: IRR or insulin receptor-related receptor is a tyrosine protein kinase that is required for the appearance of male gonads and thus for male sexual differentiation (1). The expression of IRR mRNA is restricted to a few tissue types and has been detected in neuronal tissues as well as in neuroblastomas. As a result of its occurrence in neuroblastomas, it has speculated that IRR may be involved in tumor genesis. RT-PCR and solution hybridization/RNAse protection assay have shown strong coupling of IRR mRNA in 18 tumor cell lines (2).
Description: Recombinant human Insulin receptor-related receptor (IRR), a.a. 945-end, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
Format: Aqueous buffer solution
Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Genbank: NM_014215
Host Cell Line: Sf9 cells
Purity: ≥75%
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal GST-tag
Uniprot: P14616
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Zhang, B. and Roth, R.A. The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities. J. Biol. Chem. 1992; 267 (26): 18320-8.
2. Elmlinger, M.W. et al: Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin. Regul. Pept., 1999; 84 (1-3): 37-42.
| Artikelnummer | BPS40242 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 40242 |
| Green Labware | Nein |
| Verpackungseinheit | 10 µg |
| Mengeneinheit | STK |
| Wirt | Insect |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
