Product Description: Isofistularin-3 is a direct, DNA-competitive DNMT1 inhibitor, with an IC50 of 13.5 μM. Isofistularin-3, as a DNA demethylating agent, induces cell cycle arrest and sensitization to TRAIL in cancer cells. Isofistularin-3 can be used as an ADC cytotoxin[1].
Applications: Cancer-programmed cell death
Formula: C31H30Br6N4O11
References: [1]Florean C, et al. Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells. Oncotarget. 2016 Apr 26;7(17):24027-49.
Molecular Weight: 1114.01
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: ADC Cytotoxin;Apoptosis;Autophagy;DNA Methyltransferase