JNJ-10229570, CAS 524923-88-4

Formulation: A solid

Formal Name: N-[2,3-bis(2-methoxyphenyl)-1,2,4-thiadiazol-5(2H)-ylidene]-benzenamine

Purity: ≥95%

Formula Markup: C22H19N3O2S

Formula Weight: 389,5

Shelf life (days): 1460

CAS Number: 524923-88-4

Notes: JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R), MC4R, and MC5R (IC50s = 270, 240, and 200 nM, respectively, in radioligand binding assays).{67334} It prevents bovine pituitary extract-induced increases in lipid droplets in primary human sebocytes when used at a concentration of 0.05 µM. JNJ-10229570 (1 µM) inhibits cholera toxin-induced increases in squalene and cholesterol esters, but not triglycerides, in primary human sebocytes. Topical application of JNJ-10229570 (0.05%) inhibits sebum secretion from, and sebaceous gland differentiation in, transplanted human skin in a mouse xenograft model.

• Artikelnummer: CAY37768-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37768-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe