KAT5 (TIP60), GST-Tag Recombinant

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Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. 

Background: KAT5 or K (lysine) acetyltransferase 5 is a signaling protein that belongs to the MYST family of histone acetyl transferases (HATs). KAT5 was originally isolated as an HIV-1 TAT-interactive protein that plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins (1). KAT5 protein is a histone acetylase that is involved in DNA repair and apoptosis and plays an important role in signal transduction. KAT5 acts as a cofactor of TAT that is involved in the regulation of HIV gene expression. KAT5 is also a co-regulator of transcription factors that either promote or suppress tumorigenesis (2).

Description: Full-length recombinant Human KAT5 (TIP60) protein also known as cPLA2 ESA1 HTATIP, HTATIP1, PLIP, and TIP. Genbank Accession NM_006388, with an N-terminal GST tag expressed by baculovirus in Sf9 insect cells. MW = 88kDa.

Format: Aqueous buffer solution

Formulation: 50 mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Genbank: NM_006388

Storage Stability: At least 6 months at -80°C. Avoid freeze/thaw cycles.

Tags: N-terminal GST-tag

Uniprot: Q92993

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: 1. Kamine, J. et.al. Virology. 1996; 216: 357-366.2. Gorrini, C. et al. Nature. 2007 448:1063-1067.

• Artikelnummer: BPS79422
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 79422
• Green Labware: Nein
• Verpackungseinheit: 10 µg
• Mengeneinheit: STK