English
KCNJ11 Polyclonal Antibody, Rabbit
KCNJ11 Polyclonal Antibody, Rabbit
Artikelnummer
ELSE-AB-92675-120
Verpackungseinheit
120 µl
Hersteller
Elabscience Biotechnology
Verfügbarkeit:
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Abbreviation: KCNJ11
Target Synonym: KCNJ11;BIR;HHF2;IKATP;KIR6.2;MODY13;PHHI;TNDM3
Conjugation: Unconjugated
UNIProt ID: Q14654
Background: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human KCNJ11
Dilution: WB 1:500-1:2000
Target Synonym: KCNJ11;BIR;HHF2;IKATP;KIR6.2;MODY13;PHHI;TNDM3
Conjugation: Unconjugated
UNIProt ID: Q14654
Background: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human KCNJ11
Dilution: WB 1:500-1:2000
| Artikelnummer | ELSE-AB-92675-120 |
|---|---|
| Hersteller | Elabscience Biotechnology |
| Hersteller Artikelnummer | ELA-E-AB-92675-120 |
| Green Labware | Nein |
| Verpackungseinheit | 120 µl |
| Mengeneinheit | STK |
| Reaktivität | Human, Mouse (Murine) |
| Klonalität | Polyclonal |
| Methode | Western Blotting |
| Isotyp | IgG |
| Wirt | Rabbit |
| Produktinformation (PDF) | Download |
| MSDS (PDF) | Download |
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Gernot Ensinger, M.Sc.
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