KDEL Antibody: Biotin

Rabbit Anti-KDEL Polyclonal

Target: KDEL

Conjugate: Biotin

Product Type: Polyclonal

Immunogen: KDEL containing peptide immunogen

Purification: Protein A Purified

Storage Buffer: PBS pH7.2, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Detects KDEL proteins, GRP94, Grp78, PDI and calreticulin. It may also see ERp57 and ERp29.

Cellular Localization: Endoplasmic Reticulum

Scientific Background: The endoplasmic reticulum is part of a protein sorting pathway, or in essence, the transportation system of the eukaryotic cell. The majority of endoplasmic reticulum resident proteins are retained in the endoplasmic reticulum through a retention motif. This motif is composed of four amino acids at the C-terminal end of the protein sequence. The most common retention sequence is KDEL (lys-asp-glu-leu). Grp78 and Grp94 and PDI all share the C-terminal KDEL sequence. The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER.

References: 1. Ozawa K., et al. (2008) Mol Pharmacol. 74:1610.2. Austin R.C., et al. (2003) J Biol Chem. 278: 17438.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSPC-109B-BI
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SPC-109B-BI
• Green Labware: Nein
• Verpackungseinheit: 200 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Polyclonal
• Methode: Immunofluorescence, Western Blotting, Immunohistochemistry, Immunocytochemistry
• Wirt: Rabbit