Target Synonym: KDM2A; CXXC8; FBL11; FBL7; FBXL11; JHDM1A; LILINA; lysine demethylase 2A
Storage: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants.
Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunogen: A synthetic peptide of human KDM2A
Dilution: WB 1:500-1:2000
Calculated MW: 69kDa/81kDa/89kDa/96kDa/132kDa
Observed MW: 126KDa
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