(KO Validated) TYSY Polyclonal Antibody, Rabbit

Abbreviation: TYSY

Target Synonym: TYMS; HST422; TMS; TS; thymidylate synthase

Conjugation: Unconjugated

UNIProt ID: P04818

Background: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human TYSY

Dilution: WB 1:500-1:2000,IHC 1:50-1:200,IF 1:50-1:200

• Artikelnummer: ELSE-AB-92409-200
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-E-AB-92409-200
• Green Labware: Nein
• Verpackungseinheit: 200 µl
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Polyclonal
• Methode: Immunofluorescence, Western Blotting, Immunohistochemistry
• Isotyp: IgG
• Wirt: Rabbit