KT 5823, CAS 126643-37-6

PKG kinase inhibitor

Product Type: Inhibitor

CAS No.: 126643-37-6

MolecularFormula: C29H25N3O5

Molecular Weight: 495,5

Source: Synthetic

Purity: ≥98% (TLC)

Solubility: Soluble in DMSO (20 mg/ml), dimethyl formamide (20 mg/ml) and ethyl acetate (5 mg/ml)

Appearance: White solid

PubChem CID: 3843

Scientific Background: KT5823 is a potent, selective, and reversible inhibitor of Protein Kinase G (PKG). It is a derivative of K-252a. KT5823 has been shown to inhibit SNP-stimulated PKG activity in dispersed smooth muscle cells. It has also been observed to dose-dependently inhibit spontaneous apoptosis of neutrophils.

References: 1. Murthy K.S., & Makhlouf G.M. (1995) Am J. Phys. 268(1 Pt 1): C171–180.2. Brunetti M., et al. (2002) Biochem. Biophys. Res. Comm. 297(3): 498–501.3. Kase H., et al. (1987) Biochem. Biophys. Res. Comm. 142(2): 436–440.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-458-500UG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-458-500UG
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK