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LATS1 Polyclonal Antibody, Rabbit
LATS1 Polyclonal Antibody, Rabbit
Artikelnummer
ELSE-AB-93222-60
Verpackungseinheit
60 µl
Hersteller
Elabscience Biotechnology
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Abbreviation: LATS1
Target Synonym: LATS1;WARTS;wts
Conjugation: Unconjugated
UNIProt ID: O95835
Background: The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
Concentration: 1mg/mL
Immunogen: A synthetic peptide of human LATS1
Dilution: WB 1:500-1:2000,IHC 1:50-1:200
Target Synonym: LATS1;WARTS;wts
Conjugation: Unconjugated
UNIProt ID: O95835
Background: The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
Concentration: 1mg/mL
Immunogen: A synthetic peptide of human LATS1
Dilution: WB 1:500-1:2000,IHC 1:50-1:200
| Artikelnummer | ELSE-AB-93222-60 |
|---|---|
| Hersteller | Elabscience Biotechnology |
| Hersteller Artikelnummer | ELA-E-AB-93222-60 |
| Green Labware | Nein |
| Verpackungseinheit | 60 µl |
| Mengeneinheit | STK |
| Reaktivität | Human, Mouse (Murine), Rat (Rattus) |
| Klonalität | Polyclonal |
| Methode | Western Blotting, Immunohistochemistry |
| Isotyp | IgG |
| Wirt | Rabbit |
| Produktinformation (PDF) | Download |
| MSDS (PDF) | Download |
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Gernot Ensinger, M.Sc.
Laurent Haze
