LB244

Formulation: A solid

Formal Name: (R)-N-(4-([1,1'-biphenyl]-4-carboxamido)-4-(1H-benzo[d]imidazol-2-yl)butyl)-5-nitrofuran-2-carboxamide

Purity: ≥95%

Formula Markup: C29H25N5O5

Formula Weight: 523,5

Shelf life (days): 1095

Notes: LB244 is an irreversible STING antagonist.{69623} It binds to STING in a cell-free assay and inhibits STING activation induced by the STING agonist diABZI in cells (EC50 = 0.8 nM). LB244 (1 µM) inhibits diABZI-induced STING oligomerization and phosphorylation of IFN regulatory factor 3 (IRF3) and TANK-binding kinase 1 (TBK1) in primary mouse bone marrow-derived macrophages (BMDMs). In vivo, LB244 (5 mg/kg, i.p.) reduces diABZI-induced increases in serum IL-6 and IFN-β levels in mice.

• Artikelnummer: CAY39832-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39832-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK