LCC-12 (formate)

Formulation: A solid

Formal Name: 3,18-diimino-2,4,17,19-tetraazaeicosanediimidamide, monoformate

Purity: ≥98%

Formula Markup: C16H36N10 • CH2O2

Formula Weight: 414,5

Shelf life (days): 1095

Notes: LCC-12 is a copper (II) chelator and derivative of the biguanide metformin (Item No. 13118).{51390} It binds copper (II) as a monomer and reduces its hydrogen peroxide-dependent oxidation of NADH to NAD+ when used at a concentration of 20 µM. LCC-12 (10 µM) decreases the levels of the cytokines IL-1β, IL-2, IL-6, IL-8, and TNF-α, as well as levels of JAK2, STAT2, and IL-1 receptor-associated kinase 4 (IRAK4), in primary human cytokine-activated monocyte-derived macrophages (MDMs). It reduces the numbers of CD80+ and CD86+ cytokine-activated MDMs when used at a concentration of 10 µM. LCC-12 (0.3 mg/kg per day) increases survival in mouse models of sepsis induced by LPS or cecal ligation and puncture.

• Artikelnummer: CAY38929-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38929-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK