LDN-57444, CAS 668467-91-2

DUB inhibitor

Product Type: Inhibitor

CAS No.: 668467-91-2

MolecularFormula: C17H11Cl3N2O3

Molecular Weight: 397,6

Source: Synthetic

Purity: >98%

Solubility: Soluble in 20 mg/ml DMSO

Appearance: Yellow Powder

PubChem CID: 16760696

Scientific Background: Inhibits ubiquitin C-terminal hydrolase (UCH-L1) (Ki=0.4 M). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. Cell permeable.

References: 1. Liu Y., et al. (2003) Chem. Biol. 10: 837.2. Tan Y.Y., et al. (2008) Mol. Cell. Biochem. 318: 109.3. Cartier A.E., et al. (2009) J.Neurosci. 29: 7857.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-332-10MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-332-10MG
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK