(Leu144, Arg147)-PLP (139-151) (trifluoroacetate salt)

Formulation: A crystalline solid

Formal Name: L-histidyl-L-seryl-L-leucylglycyl-L-lysyl-L-leucyl-L-leucylglycyl-L-arginyl-L-prolyl-L-α-aspartyl-L-lysyl-L-phenylalanine, trifluoroacetate salt

Purity: ≥98%

Formula Markup: C67H110N20O17 • XCF3COOH

Formula Weight: 1467,7

Shelf life (days): 1460

Notes: [Leu144,Arg147]-PLP (139-151) is a mutant peptide fragment of myelin proteolipid protein (PLP) containing tryptophan-to-leucine and histidine-to-arginine substitutions at positions 144 and 147, respectively.{67416} Immunization with [Leu144, Arg147]-PLP (139-151) (50 µg) emulsified in complete Freund’s adjuvant (CFA) increases spleen levels of IL-4 in mice. It inhibits Th1 cell activation in vitro but not in vivo, where it induces the generation of regulatory T cells.{67417} Preimmunization with [Leu144, Arg147]-PLP (139-151) delays the onset of experimental autoimmune encephalomyelitis (EAE) induced by the encephalitogenic peptides PLP (178-191), myelin oligodendrocyte protein (MOG) (92-106), or myelin basic protein (MBP) in mice.

• Artikelnummer: CAY36895-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36895-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK