Formulation: A solution in ethanol
Formal Name: (5S,6Z,8E,10E,12R,14Z)-5S,12R-dihydroxyicosa-6Z,8E,10E,14Z-tetraenoic-19,19,20,20,20-d5 acid
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C20H27D5O4
Formula Weight: 341,5
Shelf life (days): 365
Notes: Leukotriene B4-d5 (LTB4-d5) is intended for use as an internal standard for the quantification of LTB4 (Item No. 20110) by GC- or LC-MS. LTB4 is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase (5-LO) pathway.{521,719,948} It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10−10 M), LTB4 induces chemotaxis and chemokinesis in human polymorphonuclear leukocytes.{329} At higher concentrations, (1.0 x 10−7 M), LTB4 leads to neutrophil aggregation and degranulation as well as superoxide anion production.{329,82}