Scientific Background: LH 846 is a potent and selective inhibitor of Casein Kinase CK1δ. Specifically, it inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. CK1δ is a known regulator of circadian rhythm.
References: 1. Lee J.W., et al. (2011) Angewandte Chemie. 50(45): 10608–10611.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.