Lin28 Inhibitor LI71, CAS 1357248-83-9

Formulation: A solid

Formal Name: 4-[(3aS,4R,9bR)-6-ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]-benzoic acid

Purity: ≥95%

Formula Markup: C21H21NO3

Formula Weight: 335,4

Shelf life (days): 1460

CAS Number: 1357248-83-9

Notes: Lin28 inhibitor LI71 is an inhibitor of the protein-microRNA precursor interaction between the RNA-binding protein Lin28 and let-7.{68784} It binds to the cold-shock domain of Lin28 to inhibit let-7 binding and inhibits Lin28-mediated let-7 oligouridylation (IC50 = ~27 µM). Lin28 inhibitor LI71 (100 µM) increases the levels of mature let-7b, -7c, -7f, -7g, and -7i as well as the levels of miR-16, which is not regulated by Lin28, in K562 leukemia cells but not the levels of miR-93, miR-99a, and miR-151, which are also not regulated by Lin28. It increases the levels of mature let-7a-i without increasing miR-16 levels in Lin28a/Lin28b double-knockout mouse embryonic stem cells (mESCs) expressing exogenous wild-type Lin28a. Lin28 inhibitor LI71 also inhibits the protein-protein interaction between P. falciparum cold-shock protein (PfCoSP) and PfDNA or Pfα/β-tubulin.{68785} It is active against P. falciparum strain 3D7 and the chloroquine-resistant strain RKL-9 (IC50s = 1.35 and 6.3 nM, respectively).

• Artikelnummer: CAY41039-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 41039-50
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK