LNP023 (hydrochloride), CAS 1646321-63-2

Formulation: A solid

Formal Name: 4-[(2S,4S)-4-ethoxy-1-[(5-methoxy-7-methyl-1H-indol-4-yl)methyl]-2-piperidinyl]-benzoic acid, monohydrochloride

Purity: ≥98%

Formula Markup: C25H30N2O4 • HCl

Formula Weight: 459

Shelf life (days): 1460

CAS Number: 1646321-63-2

Notes: LNP023 is a complement factor B (CFB) inhibitor (IC50 = 10 nM).{64821} It is selective for CFB over a panel of 41 proteases and 110 other enzymes, receptors, and ion channels (IC50s = >30 µM for all).{64822} LNP023 inhibits formation of the membrane attack complex induced by zymosan A (Item No. 21175) in isolated human whole blood (IC50 = 150 nM).{64821} It blocks hemolysis of erythrocytes isolated from patients with paroxysmal nocturnal hemoglobinuria (IC50 = 400 nM), a disease characterized by immune-mediated red blood cell destruction, anemia, and blood clots. LNP023 (60 mg/kg twice per day) reduces levels of the alternative pathway cleavage products complement factor Ba, -C3d, and -C5a in the joints, levels of inflammatory cell infiltrates in joint tissues, and arthritis disease severity in a K/BxN serum transfer-induced mouse model of inflammatory arthritis. It also decreases proteinuria and serum levels of urea and creatine and prevents hair loss and kidney damage in an MRL-lpr mouse model of lupus nephritis when administered at a dose of 30 mg/kg per day.{64823}

• Artikelnummer: CAY37291-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37291-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK
• Methode: Reinstoffe