LP-01, CAS 1799316-64-5

Formulation: A solution in methyl acetate

Formal Name: 9Z,12Z-octadecadienoic acid, 3-[4,4-bis(octyloxy)-1-oxobutoxy]-2-[[[[3-(diethylamino)propoxy]carbonyl]oxy]methyl]propyl ester

Purity: ≥95%

Formula Markup: C50H93NO9

Formula Weight: 852,3

Shelf life (days): 730

CAS Number: 1799316-64-5

Notes: LP-01 is an ionizable cationic lipid (pKa = ~6.1).{71100} It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of single-guide RNA (sgRNA) and mRNA in vitro and in vivo.{71100,49897} LNPs containing LP-01 and encapsulating both Cas9 mRNA and modified sgRNA for the transport protein transthyretin (Ttr) induce gene editing in liver cells in mice in a dose-dependent manner resulting in reduced serum Ttr levels for at least 12 months.{71100} Subretinal administration of LNPs containing LP-01 and encapsulating both Cas9 mRNA and sgRNA targeting the loxP stop codon induce retinal gene editing in Ai9 mice.{49897}

• Artikelnummer: CAY37278-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37278-100
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK