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Biological Activity: LY171883 inhibits PDEs from human polymorphonuclear leukocytes with an IC50 of 22.6 µM, and from guinea pig tissues with an IC50 range from 6.9 - 209 µM.
CAS Number: 88107-10-2
Description: LY171883 is a PDE inhibitor and a selective, potent inhibitor of the leukotriene D4 receptor. Also, LY171883 binds to the PPAR nuclear receptor at 50-100 ?M and induces adipogenesis in cultured NIH3T3 fibroblasts.
Format: A crystalline solid
Purity: ≥98% by HPLC
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Fleisch, J.H., et al., J. Pharmacol. Exp. Ther. 1985; 233: 148-157
2. Forman, B.M., et al., Cell. 1995; 83: 803-812.
3. Tontonoz, P., et al., Cell. 1994; 79: 1147-1156.
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