LY2365109 (hydrochloride), CAS 1779796-27-8

Formulation: A solid

Formal Name: N-[2-[4-(1,3-benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methyl-glycine, monohydrochloride

Purity: ≥95%

Formula Markup: C22H27NO5 • HCl

Formula Weight: 421,9

Shelf life (days): 1460

CAS Number: 1779796-27-8

Notes: LY2365109 is an inhibitor of glycine transporter 1a (GlyT1a; IC50 = 15.8 nM in BE2-C cells expressing the human transporter).{64936} It is selective for GlyT1a over GlyT2 (IC50 = >30 µM in RD cells expressing the human transporter). LY2365109 (10 mg/kg) induces locomotor hyperactivity, impaired gait, compulsive walking, and labored breathing, as well as impairs the ability to stand, in rats.{64936} It also prevents maximal electroshock-induced acute seizures in mice and decreases the number of seizures in an electroshock-induced rat model of chronic epilepsy when administered at doses of 30 and 10 mg/kg, respectively.{64937}

• Artikelnummer: CAY37427-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37427-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK
• Methode: Reinstoffe