Product Type: Inhibitor
CAS No.: 22556-62-3
MolecularFormula: C21H41O7P*Na
Molecular Weight: 458,5
Source: Synthetic
Purity: >98% (TLC); NMR (Conforms)
Solubility: Soluble in DMSO (1 mg/ml) and warm water (10 mg/ml).
Appearance: White powder.
PubChem CID: 5311263
Scientific Background: Oleoyl-lysophosphatidic acid is an endogenous agonist of the lysophospholipid receptors LPA1 and LPA2. It has been shown to induce cellular functions such as cell proliferation and migration, and ICAM-1, IL-8 and MCP-1 expression. Lysophosphatidic acid has also been observed to inhibit autophagy in cells under starvation conditions by inhibiting autophagosome formation.
References: 1. van Corven E.J., et al. (1992) Biochem J. 281(Pt 1): 163-9.2. Chang C.L., et al. (2007) Autophagy. 3(3): 268-70.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.