Target Synonym: H2AFY; H2A.y; H2A/y; H2AF12M; MACROH2A1.1; mH2A1; macroH2A1.2; core histone macro-H2A.1
Storage: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.
Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunogen: A synthetic peptide of human macroH2A.1
Dilution: WB 1:500-1:2000
Calculated MW: 39kDa
Observed MW: Refer to figures
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