Malondialdehyde Antibody, Clone 6H6: Biotin

Mouse Anti-Malondialdehyde (MDA) Monoclonal IgG1

Target: Malondialdehyde

Conjugate: Biotin

Product Type: Monoclonal

Clone Number: 6H6

Immunogen: Synthetic Malondialdehyde modified Keyhole Limpet Hemocyanin (KLH).

Purification: Protein G Purified

Storage Buffer: PBS pH 7.4, 50% glycerol, 0.09% Sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Specific for Malondialdehyde conjugated proteins. Does not detect free Malondialdehyde. Does not cross-react with Acrolein, Crotonaldehyde, Hexanoyl Lysine, 4-Hydroxy-2-hexenal, 4-Hydroxy nonenal, or Methylglyoxal modified proteins.

Scientific Background: Malondialdehyde (MDA) is the biomarker in greatest diagnostic use, due to its molecular stability. This three-carbon, low-molecular weight aldehyde has a strong affinity for amino acids, which results in adduct formation to both free amino acids and proteins. Increased MDA levels have been found at correlating levels in breast cancer, and lung cancer patients. Other diseased states with elevated MDA levels include diabetes and Alzheimer’s disease. Multiple laboratory techniques exist for quantification of MDA levels, including the thiobarbituric acid reactive substances (TBARS) assay. In addition to use as a biomarker, MDA has been shown to have mutagenic effects on tissues themselves as adduct formation can result in DNA cross-linking.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-514D-BI
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-514D-BI
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Various species
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Western Blotting, ELISA, Flow Cytometry, Immunocytochemistry, Fluorescence-Activated Cell Sorting (FACS)
• Isotyp: IgG1
• Wirt: Mouse