MCM7 antibody (MSVA-507R) HistoMAX™

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Clone Name: MSVA-507R

Product Description: This antibody was validated on 76 different Normal Tissues by IHC-P.

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Application Note: IHC-P: 1:100-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 81

Positive Control: Colon: A strong nuclear MCM7 immunostaining should be seen in virtually all crypt base cells.

Negative Control: Colon: MCM7 immunostaining should be largely absent in surface epithelial cells and in most stroma cells.

Form: Liquid

Buffer (with preservative): 10mM PBS, 0.05% BSA (Please contact us for sodium azide-free or sodium azide and BSA-free format), 0.05% sodium azide.

Concentration: 0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot ID: P33993

Antigen Species: Human

Immunogen: Recombinant human MCM7 protein fragment (aa195-319)

Purification: Protein A/G purified

Conjugation: Unconjugated

Full Name: minichromosome maintenance complex component 7

• Artikelnummer: GTX04444-500
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX04444-500
• Verpackungseinheit: 500 μl
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (paraffin)
• Isotyp: IgG
• Human Gene ID: 4176
• Wirt: Rabbit
• Konjugat: Unconjugated