MDM2 TR-FRET Assay Kit

Products from BPS Bioscience require a minimum order value above 400€

Applications: Great for screening small molecular inhibitors for drug discovery and HTS applications.

Description: Human Casitas B-lineage lymphoma proto-oncogene b (MDM2) is an E3 ubiquitin-protein ligase that functions as a negative regulator of T-cell activation. It is a potential drug target in cancer immunotherapy. The MDM2 TR-FRET Assay Kit is designed to measure MDM2 auto-ubiquitination activity in a homogeneous 384 reaction format. It utilizes biotin-labeled ubiquitin and a terbium-labeled anti-GST antibody to complete the TR-FRET pairing. This FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications.

Storage Stability: At least 6 months from date of receipt when stored as directed.

Supplied As: The homogeneous 384 reaction format

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: 1. Wienken, M. et al., J. Mol. Cell Biol. 2017; 9(1): 74-80.
2. Shaikh, M.F. et al., Ann. Clin. Lab. Sci. 2016; 46(6): 627-34.

• Artikelnummer: BPS79773
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 79773
• Green Labware: Nein
• Verpackungseinheit: 384 rxns.
• Mengeneinheit: PAK