Mebendazole-d8, CAS 1286787-80-1

Formulation: A solid

Formal Name: methyl-d3 (6-(benzoyl-2,3,4,5,6-d5)-1H-benzo[d]imidazol-2-yl)carbamate

Purity: ≥99% deuterated forms (d1-d8)

Formula Markup: C16H5D8N3O3

Formula Weight: 303,3

Shelf life (days): 1460

CAS Number: 1286787-80-1

Notes: Mebendazole-d8 is intended for use as an internal standard for the quantification of mebendazole (Item No. 18872) by GC- or LC-MS. Mebendazole is an inhibitor of microtubule polymerization and an anthelmintic.{30620} It reduces microtubule polymerization in a cell-free assay when used at a concentration of 10 µM. Mebendazole reduces container attachment, a measure of viability, by G. duodenalis with a half-maximal inhibition of binding (IB50) value of 190 nM.{30623} It reduces the proliferation of SK-MEL-19 and M14 melanoma cell lines (IC50s = 300 and 320 µM, respectively) and induces apoptosis and poly(ADP-ribose) polymerase (PARP) cleavage in SK-MEL-19 and M14 cells, but not melanocytes, when used at a concentration of 1 µM.{30621} It decreases oxidative stress-induced cell death in primary mouse cortical neurons in a concentration-dependent manner.{30620} In vivo, mebendazole (800 µg/animal every other day) decreases tumor volume, weight, hemoglobin levels, and vascularization in an H460 lung cancer mouse xenograft model.{30624} Mebendazole (8.8 mg/kg) eradicates S. vulgaris, S. edentates, and S. equinus worm burden in infected ponies.{65906} Formulations containing mebendazole have been used in the treatment of helminth gastrointestinal infections.

• Artikelnummer: CAY40232-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 40232-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung