Melanocortin-4 Receptor Polyclonal Antibody

Formulation: 500 µl of peptide affinity-purified polyclonal antibody

Immunogen: Synthetic peptide from the N-terminal region of mouse protein MC4R

Shelf life (days): 1095

Notes: Melanocortins are known to exert a broad array of physiological actions including 'melanogenesis, steroidogenesis, sexual function and inflammation, as well as appetite regulation and energy homeostasis'.{12351} These actions are mediated (differentially or concurrently) in part by a family of G protein-coupled receptors, the melanocortin receptors 1-5 (MC1R-MC5R). Melanocortin-4 receptor (MC4R) was first cloned in 1993 with transcripts expressed primarily in the brain.{13229} Genetic studies of mice and humans have established a critical role of MC4R in appetite regulation.{3777} Heterozygous mutations in MC4R account for 1-6% of severe cases of human obesity. Thus, MC4R has been a prime target for therapeutic intervention in obesity.{10617} All known mammalian MC4Rs are 332 amino acids in length with an estimated molecular weight of 37 kDa. The protein is heavily glycosylated and appears at multiple positions on SDS-PAGE.{13230} Cayman’s MC4R Polyclonal Antibody mainly detects an unglycosylated protein at 37 kDa and a glycosylated protein at 55 kDa.

• Artikelnummer: CAY10006355-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10006355-500
• Green Labware: Nein
• Verpackungseinheit: 1 ea (500 µl)
• Mengeneinheit: STK
• Reaktivität: Mouse (Murine)
• Klonalität: Polyclonal
• Methode: Immunohistochemistry (paraffin), Western Blotting
• Wirt: Rabbit