Metformin Hydrochloride, CAS 1115-70-4

Autophagy inducer

Product Type: Inducer

CAS No.: 1115-70-4

MolecularFormula: C4H11N5•HCl

Molecular Weight: 165,6

Source: Synthetic

Purity: ≥97%

Solubility: Soluble to 100 mM in water and to 50 mM in DMSO.

Appearance: White crystalline powder.

PubChem CID: 14219

Scientific Background: Metformin Hydrochloride is an antidiabetic agent which reduces blood-glucose levels as well as improves insulin sensitivity. Metformin has also been shown to inhibit hepatic gluconeogenesis via activation of LKB1-AMPK (AMP-activated protein kinase) pathway. The activation of this pathway has also been seen to have an antiproliferative and pro-apoptotic effect in cancer cells. Lastly, Metformin is believed to induce autophagy through inhibition of the mTORC1 pathway.

References: 1. Kirpichnikov D., et al. (2002). Ann Intern Med. 137(1): 25-33.2. Caton P. W., et al. (2010). J Endocrino;. 205(1): 97-106.3. Feng Y. H., et al. (2011). J Cell Mol Med. 15(4): 825-36.4. Huang H., et al. (2013). Autophagy. 9(2): 175-95.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-395-5G
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-395-5G
• Green Labware: Nein
• Verpackungseinheit: 5 g
• Mengeneinheit: STK