MI-136, CAS 1628316-74-4

Product Description: MI-136 is an inhibitor of the menin-MLL protein-protein interaction (PPI), with an IC50 of 31 nM and a Kd of 23.6 nM. MI-136 shows to block AR signaling and has the potential for the study in castration-resistant tumors[1][2].

Applications: Cancer-programmed cell death

Formula: C23H21F3N6S

References: [1]Dmitry Borkin, et al. Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). J Med Chem. 2016 Feb 11;59(3):892-913./[2]Rohit Malik, et al. Targeting the MLL complex in castration-resistant prostate cancer. Nat Med. 2015 Apr;21(4):344-52.

CAS Number: 1628316-74-4

Molecular Weight: 470.51

Compound Purity: 99.04

Research Area: Cancer

Solubility: DMSO : 110 mg/mL (ultrasonic)

Target: Androgen Receptor;Apoptosis;Epigenetic Reader Domain

• Artikelnummer: MEXHY-19319-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-19319-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK