MK-8722, CAS 1394371-71-1

Formulation: A solid

Formal Name: 1,4:3,6-dianhydro-2-O-(5-[1,1′-biphenyl]-4-yl-6-chloro-3H-imidazo[4,5-b]pyridin-2-yl)-D-mannitol

Purity: ≥95%

Formula Markup: C24H20ClN3O4

Formula Weight: 449,9

Shelf life (days): 1460

CAS Number: 1394371-71-1

Notes: MK-8722 is an activator of AMP-activated protein kinase (AMPK).{51531} It activates Ampk and increases phosphorylated acetyl-CoA carboxylase 1 (Acc1) levels in primary mouse dorsal root ganglia (DRG) when used at concentrations of 0.1 and 10 µM. MK-8722 (20 and 50 µM) reduces the proliferation, colony formation, migration, and invasion of, and induces apoptosis in, PANC-1 and PaTu 8988 pancreatic cancer cells.{51533} It induces cell cycle arrest at the G2 phase in PANC-1 and PaTu 8988 cancer cells when used at a concentration of 50 µM. In vivo, MK-8722 (25 mg/kg per day) reduces tumor volume and weight in a PANC-1 mouse xenograft model. It decreases blood glucose levels in fasting and glucose-challenged mice in a mouse model of diabetes induced by a high-fat diet when administered at doses of 10 and 30 mg/kg.{51532} MK-8722 (30 mg/kg) increases the paw withdrawal threshold in the von Frey test in mice.{51531}

• Artikelnummer: CAY37578-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37578-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK