Formulation: A crystalline solid
Formal Name: α-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thiopheneacetamide
Purity: ≥95%
Formula Markup: C23H22Cl2N2O3S
Formula Weight: 477,4
Shelf life (days): 1460
CAS Number: 1035072-16-2
Notes: ML-162 is an inhibitor of glutathione peroxidase 4 (GPX4).{57628} It decreases GPX4 levels in MDA-MB-231 breast cancer cells, as well as the viability of BT-549 breast cancer cells, an effect that is enhanced by α-eleostearic acid (9(Z),11(E),13(E)-octadecatrienoic acid; Item No. 10008349). ML-162 is also selectively lethal to mutant RAS oncogene-expressing cells (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type RAS-expressing BJeH cells, respectively).{33150}