ML-184, CAS 794572-10-4

Product Description: ML-184 (CID2440433) is a selective GPR55 agonist with an EC50 of 250 nM and exhibits >100-fold selectivity for GPR55 over GPR35, CB1 and CB2. ML-184 induces phosphorylation of ERK1/2 and translocation of PKCβII to the plasma membrane by activating GPR55[1]. ML-184(CID2440433) increases proliferation of neural stem cells and promotes neuronal differentiation in vitro[2].

Applications: Neuroscience-Neuromodulation

Formula: C25H34N4O3S

References: [1]Kotsikorou E, et al. Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry. 2011 Jun 28;50(25):5633-47./[2]Hill JD, et al. Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Br J Pharmacol. 2018 Aug;175(16):3407-3421. 

CAS Number: 794572-10-4

Molecular Weight: 470.63

Compound Purity: 99.57

Research Area: Neurological Disease

Solubility: DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)

Target: GPR55

• Artikelnummer: MEXHY-116461-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-116461-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK