MLH1 antibody (ES05)

Clone Name: ES05

Application Note: IHC-P: 1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 85

Form: Liquid

Buffer (with preservative): Tissue culture supernatant, 0.09% Sodium azide.

Concentration:

Background: The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]

Uniprot ID: P40692

Antigen Species: Human

Immunogen: Prokaryotic recombinant protein corresponding to 210 amino acids of human MLH1.

Purification: Unpurified

Conjugation: Unconjugated

Full Name: mutL homolog 1

• Artikelnummer: GTX01906-500
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX01906-500
• Green Labware: Nein
• Verpackungseinheit: 500 μl
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (paraffin)
• Isotyp: IgG1
• Human Gene ID: 4292
• Wirt: Mouse