MLKL (phospho Ser358) antibody

Application Note: WB: 1:500-1:2000. IHC-P: 1:50-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 54

Form: Liquid

Buffer (with preservative): PBS, 150mM NaCl, 50% Glycerol, 0.02% Sodium azide.

Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)

Background: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]

Uniprot ID: Q8NB16

Antigen Species: Human

Immunogen: A synthesized peptide derived from human MLKL around the phosphorylation site of Ser358.

Purification: Purified by sequential chromatography on phospho-peptide and non-phospho-peptide columns

Conjugation: Unconjugated

Full Name: mixed lineage kinase domain like pseudokinase

• Artikelnummer: GTX00973-100
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX00973-100
• Green Labware: Nein
• Verpackungseinheit: 100 μl
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Polyclonal
• Methode: Immunohistochemistry (paraffin), Western Blotting, ELISA
• Isotyp: IgG
• Human Gene ID: 197259
• Wirt: Rabbit