Formulation: A crystalline solid
Formal Name: 4-carboxy-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-acetic acid
Purity: ≥95%
Formula Markup: C20H23BCl2N2O9
Formula Weight: 517,1
Shelf life (days): 1460
CAS Number: 1201902-80-8
Notes: MLN9708 is a prodrug form of the proteasome inhibitor MLN2238 (Item No. 18385).{31628,31627} It is converted to MLN2238 via hydrolysis in the plasma.{31628} MLN9708 inhibits the 20S proteasome (IC50 = 8.4 nM for the human enzyme) and binds to caseinolytic protease P (Kd = 7,300 nM for the S. aureus enzyme).{57957,58924} It inhibits the proliferation of RPMI-8226, U266B, and ARH-77 multiple myeloma cells with IC50 values of 49.4, 67, and 43.5 nM, respectively.{57957}