MNK1 Kinase Assay Kit

Products from BPS Bioscience require a minimum order value above 400€

Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.

Background: MAPK-interacting serine/threonine-protein kinase 1 (MNK1) is a member of the serine/threonine family that plays a role in mitotic cell cycle progression. Alteration of MNK1 has been shown in various cancers such as breast carcinoma and melanoma. MNK1 phosphorylates eukaryotic translation initiation factor 4E (eIF4E), enhancing phosphorylation of quiescent cells and rendering eIF4E oncogenic.

Description: The MNK1 Kinase Assay Kit is designed to measure MNK1 kinase activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent. 

Storage Stability: Up to 6 months when stored as recommended.

Supplied As: The MNK1 Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant MNK1 enzyme, MBP, ATP, and kinase assay buffer for 100 enzyme reactions.

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: 1. Chrestensen, C.A., et al. 2007. "MNK1 and MNK2 regulation in HER2-overexpressing breast cancer lines." Journal of Biological Chemistry 282(7): 4243-4252.
2. Dreas, A., et al. 2017. "Mitogen-activated protein kinase (MAPK) interacting kinases 1 and 2 (MNK1 and MNK2) as targets for cancer therapy: recent progress in the development of MNK inhibitors." Current Medicinal Chemistry 24(28): 3025-3053.

• Artikelnummer: BPS78032
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 78032
• Green Labware: Nein
• Verpackungseinheit: 96 rxns.
• Mengeneinheit: PAK