MOMIPP, CAS 1363421-46-8

Formulation: A solid

Formal Name: (2E)-3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one

Purity: ≥98%

Formula Markup: C18H16N2O2

Formula Weight: 292,3

Shelf life (days): 1460

CAS Number: 1363421-46-8

Notes: MOMIPP is an inhibitor of PIKfyve (IC50 = 5.05 nM).{65882} It selectively binds to PIKfyve over phosphatidylinositol 4-phosphate 5-kinase type-1 γ (PIP5K1C; Kds = 5.3 and >15,000 nM, respectively). MOMIPP (10 µM) induces vacuolization and cell lysis, markers of methuosis, and decreases the extracellular acidification rate (ECAR), indicating inhibition of glycolytic flux, but not the oxygen consumption rate (OCR), in U251 glioblastoma cells.{65883} Intraperitoneal administration of MOMIPP (80 mg/kg) decreases tumor growth in a U251 orthotopic mouse xenograft model.

• Artikelnummer: CAY39671-250
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39671-250
• Green Labware: Nein
• Verpackungseinheit: 250 mg
• Mengeneinheit: STK