Mouse anti-Annexin A1, clone MRQ-3

Clone Number: MRQ-3

Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers

Concentration: n/a

Storage buffer: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide

Additional info: Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans.Annexin A1 is a useful marker for identifying hairy cell leukemia cells. ANXA1 is strongly expressed onthe cell membrane and occasionally in the cytoplasm of tumor cells in 97% of samples from patientswith hairy cell leukemia, it is therefore a useful marker for identifying hairy cell leukemia cells. By contrast,B-cell lymphomas other than hairy cell leukemia, including typical splenic lymphoma with villouslymphocytes and patients with variant hairy cell leukemia—as defined by current morphologic,phenotypic, and clinical criteria—are ANXA1-negative. Additionally, aberrant expression of Annexin A1has been reported in certain types of breast and gastric carcinomas.

References: Falini B, et al. Lancet.; 363:1869-70 (2004)/Sobral-Leite M, et al. BMC Med.; 13:156 (2015)/Cheng TY, et al. Cancer.; 118:5757-67 (2012)

• Artikelnummer: SANMON-RTU1213
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON-RTU1213
• Verpackungseinheit: 7 ml
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (paraffin)
• Isotyp: IgG1
• Wirt: Mouse
• Konjugat: Unconjugated