Mouse anti-Beta-Catenin, clone 17C2 (monoclonal)

Clone Number: 17C2

Immunogen: Prokaryotic recombinant protein corresponding to a 160 amino acid region of the C-terminus of the beta-catenin molecule.

Concentration: Greater than or equal to 51 mg/L

Storage buffer: Tissue culture supernatant with sodium azide

Additional info: The catenins, (alpha, beta and gamma) are cytoplasmic proteins which bind to the highly conserved tail of the E-cadherin molecule. Beta-catenin is a component of the adherens junction, a multiprotein complex which supports Ca2+ -dependent cell-to-cell contact, which in itself is critical for adhesion, signal transmission and for anchoring the actin cytoskeleton. Beta-catenin's role is as a transcription effector of the wnt-signaling pathway. Immunohistochemistry is the best way to demonstrate nuclear expression of beta-catenin and wnt-pathway activation. This aberrant expression is observed in human tumorigenesis, and especially in colorectal cancer.

References: Curia MC et al. Modern Pathology. 2008; 21:7-14/Ortega P et al. Clinical Cancer Research. 2008; 14(14):995-1001/Daa T et al. J. of Exp.Clin.Cancer Research. 2005; 24(1):83-87

• Artikelnummer: SANMONX10872
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MONX10872
• Green Labware: Nein
• Verpackungseinheit: 1 ml
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (paraffin)
• Isotyp: IgG2a
• Wirt: Mouse