Mouse anti-CD18, clone 68-5A5 (Monoclonal)

Clone Number: 68-5A5

Immunogen: human PBLs

Concentration: 100 ug/ml

Storage buffer: PBS with 0.02% sodium azide

Additional info: It recognizes a transmembrane glycoprotein of 95 kDa, identified as CD18 or intergrin-2 (Workshop III). It complexes non-covalently with either L, M, or X integrin (CD11a, b, or c) to form the heterodimers. LFA-1, MAC-1, and p150,95, respectively. LFA-1 is the receptor for three members of the Ig supergene family of proteins, ICAM-1 (CD54, ICCAM-2 (CD102), and Mac-1 and p150,95 bind to ICAM-1, fibrinogen, and IC3b. ICAM-3 (CD50). CD18/CD11 heterodimeric molecules are involved with cell/cell and cell/extracellular adhesion in immune and inflammatory responses. This Mab blocks these cellular interactions. 68-5A5 was clustered at the IIIrd International Workshop on human leucocyte differentiation antigens.

References: McMichael A.J.et al., Leucocyte typing III, Oxford University Press, Oxford, (1987)

• Artikelnummer: SANMON9925
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON9925
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunohistochemistry (frozen), Western Blotting, Flow Cytometry, Functional Assay
• Isotyp: IgG2a-k
• Wirt: Mouse