Mouse anti-CD19, clone LT19, R-PE (Monoclonal)

Clone Number: LT19

Conjugate: PE

Immunogen: Daudi human Burkitt lymphoma cell line

Concentration: n/a

Storage buffer: Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide

Additional info: CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.

• Artikelnummer: SANMON1200R
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON1200R
• Green Labware: Nein
• Verpackungseinheit: 100 tests
• Mengeneinheit: PAK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Flow Cytometry
• Isotyp: IgG1
• Wirt: Mouse