Mouse anti-CD222, clone MEM-238 (Monoclonal)

Clone Number: MEM-238

Immunogen: Recombinant Vaccinia virus encoding CD222.

Concentration: 1 mg/ml

Storage buffer: Phosphate buffered saline (PBS) solution with 15 mM sodium azide

Additional info: CD222 (CIMPR, cation-independent mannose 6-phosphate receptor; IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria.

• Artikelnummer: SANMON2064
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON2064
• Green Labware: Nein
• Verpackungseinheit: 0,1 mg
• Mengeneinheit: STK
• Reaktivität: Human, Primate
• Klonalität: Monoclonal
• Methode: Immunoprecipitation, Western Blotting, Flow Cytometry
• Isotyp: IgG1
• Wirt: Mouse