Mouse anti-Hu CD117 Purified, clone 104D2 (Monoclonal)

Clone Number: 104D2

Immunogen: MOLM-1 megakaryocytic cells

Concentration: 1 mg/ml

Format: Purified by protein-A affinity chromatography.

Storage buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Additional info: CD117 / c-Kit (stem cell factor receptor) is a 145 kDa receptor tyrosine kinase that regulates cell proliferation, adhesion, chemotaxis, apoptosis and other cell processes. Mutations of CD117 / c-Kit can lead to growth and progression of tumours. After binding of its ligand, SCF (stem cell factor), CD117 / c-Kit is autophosphorylated on its intracellular domains and activated. CD117 is expressed on pluripotent hematopoietic progenitor cells, mast cells and various cancer cells, e.g. acute myeloid leukemia cells.SpecificityThe mouse monoclonal antibody 12D3 recognizes an extracellular epitope of CD118, a transmembrane glycoprotein, which associates with CD130 to form the functional high affinity LIF receptor.Application detailsFlow cytometry: Recommended dilution: 1 μg/ml.

• Artikelnummer: SANMON23076
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON23076
• Green Labware: Nein
• Verpackungseinheit: 0,1 mg
• Mengeneinheit: STK
• Reaktivität: Human, Primate, Cow (Bovine)
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (frozen), Immunoprecipitation, Flow Cytometry, Immunocytochemistry
• Isotyp: IgG1 kappa
• Wirt: Mouse