Mouse anti-Hu CD118 Purified, clone 12D3 (Monoclonal)

Clone Number: 12D3

Immunogen: human recombinant soluble CD118-Fc

Concentration: 1 mg/ml

Format: Purified by protein-A affinity chromatography.

Storage buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Additional info: CD118 (LIFR alpha) is a type I transmembrane glycoprotein of the cytokine receptor family, which associates noncovalently with CD130 to form the functional high affinity LIF receptor, which also acts as an oncostatin M receptor. CD118 alone binds LIF with low affinity. A secreted form of CD118 results from alternative splicing, and may have inhibitory effect, as it also binds LIF, although with low affinity. CD118 is not expressed on lymphocytes, but it is widely expressed outside the immune system. Soluble CD118 level rises during pregnancy, in parallel with a drop in circulating LIF levels.SpecificityThe antibody MEM-174 recognizes an extracellular epitope of CD11b antigen (Mac-1 alpha), a 165-170 kDa type I transmembrane protein mainly expressed on monocytes, granulocytes and NK-cells. The CD11b mediates neutrophil and monocyte interactions with stimulated endothelium.Application detailsFlow cytometry: Recommended dilution: 2-5 μg/ml.

• Artikelnummer: SANMON23077
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON23077
• Verpackungseinheit: 0,1 mg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Western Blotting, ELISA, Flow Cytometry
• Isotyp: IgG1 kappa
• Wirt: Mouse
• Konjugat: Unconjugated