Mouse anti-Hu CD266 Purified, clone ITEM-4 (Monoclonal)

Clone Number: ITEM-4

Immunogen: human CD266-transfected P815 cells

Concentration: 1 mg/ml

Format: Purified by protein-A affinity chromatography.

Storage buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Additional info: CD266 / TWEAK R (TNFRSF12A), also known as FN14 (fibroblast growth factor-inducible 14) is a receptor for CD255 / TWEAK, the TNF-like weak inducer of apoptosis. CD266 is expressed on endothelial cells, as well as on some cancer tissues, and plays a role in CD255-induced endothelial cell migration, proliferation, and angiogenesis. The CD255-CD266 interaction, or antibody-mediated triggering of CD266 is also able to induce apoptosis and necrosis in CD266-positive cells (including tumor cells), which might have therapeutic potential.SpecificityThe mouse monoclonal antibody 11C1 recognizes an extracellular epitope of CD268 / BAFF R (B cell-activating factor receptor), a 19 kDa type III transmembrane protein expressed on resting B cells and CD4-positive T cells, but down regulated after activation.Application detailsFlow cytometry: Recommended dilution: 1-4 µg/ml

• Artikelnummer: SANMON23154
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON23154
• Verpackungseinheit: 0,1 mg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine)
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (frozen), Western Blotting, Flow Cytometry
• Isotyp: IgG2b
• Wirt: Mouse
• Konjugat: Unconjugated