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Mouse anti-Hu CD79a Purified, clone HM57 (Monoclonal)
Mouse anti-Hu CD79a Purified, clone HM57 (Monoclonal)
Artikelnummer
SANMON23227
Verpackungseinheit
0,1 mg
Hersteller
Sanbio / Monosan
Verfügbarkeit:
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Clone Number: HM57
Immunogen: Synthetic peptide corresponding to amino acids 202-216 of human CD79a
Concentration: 1 mg/ml
Format: Purified by protein-A affinity chromatography.
Storage buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Additional info: CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.SpecificityThe mouse monoclonal antibody CB3-1 recognizes an extracellular epitope of CD79b (CD79 beta, Ig beta), an approximately 38 kDa component of B cell receptor (BCR) complex.Application detailsFlow cytometry: Recommended dilution: 5 μg/ml. Intracellular staining.
Immunohistochemistry (paraffin sections): Recommended dilution: 10 μg/ml.
Immunohistochemistry (frozen sections): Recommended dilution: 10 μg/ml.
Immunogen: Synthetic peptide corresponding to amino acids 202-216 of human CD79a
Concentration: 1 mg/ml
Format: Purified by protein-A affinity chromatography.
Storage buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Additional info: CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.SpecificityThe mouse monoclonal antibody CB3-1 recognizes an extracellular epitope of CD79b (CD79 beta, Ig beta), an approximately 38 kDa component of B cell receptor (BCR) complex.Application detailsFlow cytometry: Recommended dilution: 5 μg/ml. Intracellular staining.
Immunohistochemistry (paraffin sections): Recommended dilution: 10 μg/ml.
Immunohistochemistry (frozen sections): Recommended dilution: 10 μg/ml.
| Artikelnummer | SANMON23227 |
|---|---|
| Hersteller | Sanbio / Monosan |
| Hersteller Artikelnummer | MON23227 |
| Green Labware | Nein |
| Verpackungseinheit | 0,1 mg |
| Mengeneinheit | STK |
| Reaktivität | Human, Mouse (Murine), Rat (Rattus), Pig (Porcine), Rabbit, Guinea Pig, Various species, Cow (Bovine), Chicken, Horse (Equine) |
| Klonalität | Monoclonal |
| Methode | Immunohistochemistry (frozen), Immunohistochemistry (paraffin), Flow Cytometry |
| Isotyp | IgG1 |
| Wirt | Mouse |
| Produktinformation (PDF) |
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| MSDS (PDF) |
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Gernot Ensinger, M.Sc.
Laurent Haze
