Mouse anti Human CD34, conjugated with FITC

Mouse anti Human CD34, conjugated with FITC, IgG1, Clone: CS37

Clone: CS37

Background: Human Progenitor Cell Antigen (MW 115 K daltons) is found on normal peripheral blood lymphocytes, monocytes, granulocytes and platelets. CD34 is present on 1% or less of cells in normal human bone marrow. Human Progenitor Cell Antigen reacts with 30-70% of acute leukemias, as well as all TdT positive lymphocytes in bone marrow.

Immunogen: CD34=Derived from the hybridization of mouse Sp2/O-Ag14 cells with spleen cells of BALB/c mice immunized with human cell line KG-1a

Purification Method: Protein A/G Chromatography

Concentration: Titered for flow cytometry

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide and 0.2% carrier protein

References: 1. Antigenic Analysis of Hematopoiesis III. A Hematopoietic Progenitor Cell Antigen Defined by a Monoclonal Antibody raised against KG-1a cells Civin, C.I., Strauss,L.C., Broveal,C., Fackler,M.J., Schwartz,J.F., and Shaper,J.H., J. Immunol. 133,157,1984 2. Rapid isolation of human CD34 hematopoietic stem cells--purging of human tumor cells. Lebkowski JS; Schain LR; Okrongly D; Levinsky R; Harvey MJ; Okarma T Transplantation 1992 May;53(5):1011-9 3. Distribution of surface-membrane molecules on bone marrow and cord blood CD34+ hematopoietic cells. Saeland S; Duvert V; Caux C; Pandrau D; Favre C; Valle A; Durand I; Charbord P; de Vries J; Banchereau J Exp Hematol 1992 Jan;20(1):24-33 4. CD34-positive cell proportions in peripheral blood correlate with colony-forming capacity. Fritsch G; Emminger W; Buchinger P; Printz D; Gadner H Exp Hematol 1991 Dec;19(11):1079-83 5. CD34 expression by stromal precursors in normal human adult bone marrow. Simmons PJ; Torok-Storb B Blood 1991 Dec 1;78(11):2848-53 6. Human CD34+ HLA-DR- bone marrow cells contain progenitor cells capable of self-renewal, multilineage differentiation, and long-term in vitro hematopoiesis. Srour EF; Brandt JE; Briddell RA; Leemhuis T; van Besien K; Hoffman R Blood Cells 1991;17(2):287-95 7. Surface marker expression in acute myeloid leukaemia at first relapse. Thomas X; Campos L; Archimbaud E; Shi ZH; Treille-Ritouet D; Anglaret B; Fiere D Br J Haematol 1992 May;81(1):40-4 Product Specific References: 1. Gardner, J.P. et al. 'Robust, but transient expression of adeno-associated virus-transduced genes during human t lymphopoisis.' Blood, 1997, 90, 4854-4864.

UniProt: P28906

Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

• Artikelnummer: EXA0342
• Hersteller: Exalpha Biologicals Inc
• Hersteller Artikelnummer: 0342
• Verpackungseinheit: 100 Tests
• Mengeneinheit: PAK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Flow Cytometry
• Isotyp: IgG1
• Wirt: Mouse
• Konjugat: Conjugated, FITC