Mouse anti-LARGE1 Purified, clone LARGE-02 (Monoclonal)

Clone Number: LARGE-02

Immunogen: Recombinant fragment of human LARGE1 (amino acids 35-142)

Concentration: 1 mg/ml

Format: Purified by protein-A affinity chromatography.

Storage buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Additional info: LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.SpecificityThe antibody LST1/02 reacts with an extracellular epitope of LST1, an approximately 6-11 kDa protein expressed as various transmembrane or soluble forms. LST1 is found predominantly on monocytes and dendritic cells. It migrates on SDS PAGE gels as approximately 25-28 kDa molecule.Application detailsFlow cytometry: Recommended dilution: 1-5 μg/ml. Intracellular staining.

• Artikelnummer: SANMON23280
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON23280
• Verpackungseinheit: 0,1 mg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Western Blotting, Flow Cytometry
• Isotyp: IgG2b
• Wirt: Mouse
• Konjugat: Unconjugated