Mouse anti-Multiple Myeloma Oncogene 1 (MUM-1), Clone EAU32 (monoclonal)

Clone Number: EAU32

Immunogen: Prokaryotic recombinant protein corresponding to 313 amino acids of the human multiple myeloma oncogene 1 (MUM-1) molecule.

Concentration: Greater than or equal to 263 mg/L

Storage buffer: Tissue culture supernatant with sodium azide

Additional info: The MUM-1 (multiple myeloma oncogene 1) gene was originally identified because of its involvement in the t(6:14) translocation observed in multiple myeloma, which causes the juxtaposition of the MUM-1 gene to the Ig heavy chain locus. MUM-1 is expressed in late plasma cell directed stages of B cell differentiation and in activated T cells, suggesting that MUM-1 may serve as a marker for lympho-hemopoietic neoplasms derived from these cells. The morphologic spectrum of MUM-1 expressing cells has been found to range from that of a centrocyte to that of a plasmablast/plasma cell. Consequently the histogenic value of MUM-1 may be to provide a marker to aid in the identification of the transition from BCL-6 positive (germinal center B cells) to CD138 positive (immunoblasts and plasma cells).

References: Bergsagel P and Kuehl W.Oncogene. 2001: 20(40);5611-5622/Iida S et al. Nature Genetics. 1997:17(2);226-230

• Artikelnummer: SANMONX11127
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MONX11127
• Green Labware: Nein
• Verpackungseinheit: 1 ml
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (paraffin)
• Isotyp: IgG1
• Wirt: Mouse